The first map of lipids in the mouse brain
EPFL scientists have created a detailed atlas of lipids across the entire mouse brain, identifying 539 distinct territories called lipizones based on 172 lipid species measured with MALDI-MSI. The atlas reveals that lipid patterns align with known anatomy and uncover new chemical boundaries, and it also documents significant lipid changes during pregnancy. The data and machine‑learning tools used to build the 3‑D model are freely available online.
EPFL scientists have created a detailed atlas of lipids across the entire mouse brain, identifying 539 distinct territories called lipizones based on 172 lipid species measured with MALDI-MSI. The atlas reveals that lipid patterns align with known anatomy and uncover new chemical boundaries, and it also documents significant lipid changes during pregnancy. The data and machine‑learning tools used to build the 3‑D model are freely available online.
The project demonstrates how AI-driven image analysis can transform high‑throughput lipidomics, offering a Swiss‑based example of applying machine learning to complex biological imaging data.
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