Differences in microbiota profiles of simple and complicated pediatric appendicitis cases
This study compared microbial composition between simple appendicitis (SA) and complicated appendicitis (CA) in pediatric patients using culture and 16S rRNA sequencing of appendix tissues and rectal swabs. The most common aerobic bacteria identified were Escherichia, Klebsiella spp., and Enterococcus spp., and CA samples showed higher relative abundance of potential pathobionts such as an unclassified Enterobacteriaceae genus. No significant differences were found at the alpha or beta diversity levels between SA and CA groups, and the study highlighted limitations including a small sample si…
This study compared microbial composition between simple appendicitis (SA) and complicated appendicitis (CA) in pediatric patients using culture and 16S rRNA sequencing of appendix tissues and rectal swabs. The most common aerobic bacteria identified were Escherichia, Klebsiella spp., and Enterococcus spp., and CA samples showed higher relative abundance of potential pathobionts such as an unclassified Enterobacteriaceae genus. No significant differences were found at the alpha or beta diversity levels between SA and CA groups, and the study highlighted limitations including a small sample si…
The findings suggest that microbiota profiling could inform predictive modeling for appendicitis severity, a research area that aligns with Swiss AI initiatives focused on developing data-driven diagnostic tools.
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