Cracking the code of gene regulation
EPFL researchers contributed to the creation of the most comprehensive catalogue of human transcription factor DNA‑binding motifs, the Codebook, by performing 4,800 experiments and identifying 177 previously poorly characterized factors. A companion study from the same lab introduced meSMiLE‑seq, a microfluidic assay that compares transcription factor binding to methylated versus unmethylated DNA, revealing that DNA methylation can alter binding affinity for 48 factors. Together, the studies expand the known DNA sequence vocabulary and show how epigenetic marks modulate gene regulation, offer…
EPFL researchers contributed to the creation of the most comprehensive catalogue of human transcription factor DNA‑binding motifs, the Codebook, by performing 4,800 experiments and identifying 177 previously poorly characterized factors. A companion study from the same lab introduced meSMiLE‑seq, a microfluidic assay that compares transcription factor binding to methylated versus unmethylated DNA, revealing that DNA methylation can alter binding affinity for 48 factors. Together, the studies expand the known DNA sequence vocabulary and show how epigenetic marks modulate gene regulation, offer…
The work, supported by the Swiss National Science Foundation and conducted at EPFL, demonstrates how Swiss research contributes to foundational genomic resources that can be leveraged by AI-driven analyses of gene regulation and disease mechanisms.
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